Researchers have been testing GDF11 in mice for years, focusing mainly on its positive effects on the heart. But the results from the most recent studies are dramatic: older mice were able to navigate mazes faster, run longer on treadmills, and demonstrated a better sense of smell. And the reverse appeared to be true as well—young mice injected with old blood had noticeable difficulties afterwards.link to article here.
After four to five weeks of heterochronic parabiosis, the Science study found that muscle stem cells from the older partners had less DNA damage compared with controls. Their neural stem cells got a boost of activity as well, and they had a greater amount of blood flow in their brains.
Then the researchers switched to pure GDF11 injections. When they gave a new group of aged mice four weeks of treatment, they found that the protein itself gave similar enhancements as shared circulation. There were more stem cells in their muscles to create new tissue, and they performed better on strength and endurance tests than controls given saline. GDF11 treatment also increased the amount of blood vessels in their brains.
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